Front Cover: Direct Addition of Grignard Reagents to Aliphatic Carboxylic Acids Enabled by Bulky turbo ‐Organomagnesium Anilides (Chem. Eur. J. 9/2022)
نویسندگان
چکیده
Grignard reagents (R-Mg-X) are commercial carbon nucleophiles commonly used in organic synthesis, but their stability becomes a limitation for the least-reactive electrophiles. A bulky magnesium anilide additive (in purple) generates new organometallic reagent (R−Mg-NHAr) situ that boosts nucleophilicity and selectivity of ligand green). In Research Article by A. Mendoza co-workers (DOI: 10.1002/chem.202104053), these prove to be instrumental direct synthesis ketones from carboxylic acids, transformation was only possible with some organolithium before.
منابع مشابه
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ژورنال
عنوان ژورنال: Chemistry: A European Journal
سال: 2022
ISSN: ['0947-6539', '1521-3765']
DOI: https://doi.org/10.1002/chem.202200294